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Acute Retinal Necrosis: Experience in a Reference Center in Santander - Colombia
Carlos Mario Rangel1,2,3, Marcos Restrepo-Arango4, Germán Mejía-Salgado5
1Universidad Autónoma de Bucaramanga (UNAB), Bucaramanga, Santander, Colombia.
Introduction:
Acute retinal necrosis (ARN) is a severe eye disease demanding swift treatment to prevent blindness. Early action involving antiviral medications and corticosteroids is crucial for optimal visual outcomes.
Objective:
We present an ARN case series showcasing treatment experience and results.
Methodology:
Patients diagnosed with ARN based on SUN Working Group 2021 criteria were included; all underwent comprehensive eye exams, PCR analysis, and imaging.
Results:
Eight patients were studied; PCR confirmed ARN in six. Induction treatment, either oral valacyclovir (5/8) or intravenous acyclovir (3/8), lasted 10-14 days. Maintenance included oral valacyclovir (6/8), oral valganciclovir (2/8) for six months, along with intravitreal ganciclovir. Visual outcomes were similar for oral and intravenous therapies; poor baseline acuity and macular involvement tend to result in a worse final acuity.
Conclusions:
Swift treatment is vital to ARN management. Our findings emphasize effective treatment strategies' role in visual prognosis.
Abbreviations:
ACV: Acyclovir; BCVA: Best Corrected Visual Acuity; CMV: Cytomegalovirus; EBV: Epstein Barr Virus; FTA-ABS: Fluorescent treponemal antibody absorption test; HSV 1-2: Herpes simplex virus 1-2; HIV: Human Immunodeficiency Virus; IV-ACV: Intravenous- Acyclovir; PCR: Polymerase Chain Reaction;Tg: Toxoplasma gondii; VZV: Varicella Zoster Virus; VCV: Valacyclovir; VDRL: Venereal disease research laboratory test.
