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UNILATERAL ROTH SPOTS AS AN INITIAL PRESENTATION IN ESSENTIAL THROMBOCYTHEMIA
Fitz Gerald I Diala1,2,3, Ramoncito L Caleon4, Ali Mahdavi Fard5
1UCLA Medical Scientist Training Program, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Retinal Cases & Brief Reports
|August 15, 2023
Summary
Unilateral Roth spots in a young woman led to the diagnosis of essential thrombocythemia (a blood disorder). Prompt treatment with aspirin resolved her visual symptoms and fundus findings.
Area of Science:
- Ophthalmology
- Hematology
- Internal Medicine
Background:
- Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
- ET can manifest with diverse symptoms, including ocular complications.
- Roth spots are intraretinal hemorrhages that can indicate underlying systemic disease.
Purpose of the Study:
- To report a case of essential thrombocythemia presenting initially with unilateral Roth spots.
- To highlight the importance of investigating ocular findings for systemic pathology.
Main Methods:
- A case report detailing a 25-year-old female patient.
- Ophthalmic examination including dilated funduscopy.
- Laboratory workup for thrombocythemia, including JAK2 mutation analysis.
Main Results:
- The patient presented with visual disturbances and unilateral Roth spots.
- Diagnosis of essential thrombocythemia confirmed by thrombocytosis and JAK2 (V617F) mutation.
- Ocular findings and symptoms resolved within one month of low-dose aspirin treatment.
Conclusions:
- Roth spots can be an early indicator of essential thrombocythemia.
- Systemic evaluation is crucial when Roth spots are identified.
- Early diagnosis and treatment of ET are vital due to its potential for serious complications.
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