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Author Spotlight: Assessing Ischemic Stroke Damage Through Middle Cerebral Artery Occlusion Model
Published on: August 11, 2023
Obesity-hyperlipidemia, Hypertension, and Left Atrial Enlargement During Stroke in Young Adults
1Department of Neurology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, Jiangsu, People's Republic of China.
Insights
Left atrial enlargement in young adults is not linked to stroke severity. However, obesity, hyperlipidemia, and hypertension are significant risk factors for left atrial enlargement in young stroke patients.
Area of Science:
- Cardiology
- Neurology
- Public Health
Background:
- Investigates the link between left atrial enlargement and stroke severity in young adults.
- Examines clinical data differences between normal and enlarged left atrial groups.
Purpose of the Study:
- To determine the association between left atrial size and stroke severity in young adults.
- To identify clinical factors associated with left atrial enlargement in this demographic.
Main Methods:
- Recruited 135 young stroke patients (Jan 2018-Dec 2021).
- Classified patients into normal and enlarged left atrial groups based on size.
- Analyzed the relationship between left atrial diameter and NIH Stroke Scale score, alongside clinical variables.
Main Results:
- No significant correlation found between left atrial diameter and NIH Stroke Scale score (r=-0.045, P=0.603).
- Hypertension, hyperlipidemia, elevated BMI, and obesity were associated with left atrial enlargement.
- Logistic regression identified hyperlipidemia, hypertension, and obesity as significant predictors of left atrial enlargement in young stroke patients.
Conclusions:
- Obesity, hyperlipidemia, and hypertension are significantly associated with left atrial enlargement in young adults experiencing stroke.
- These factors are key indicators for left atrial enlargement in younger stroke populations.
Background:
This study investigated the association between left atrial enlargement and stroke severity in young adults. We also studied the differences between the normal and left atrial enlargement groups in clinical data.
Methods:
A total of 135 young stroke patients admitted to the Department of Neurology of the Taizhou People's Hospital were recruited from January 2018 to December 2021. The patients were divided into normal and enlarged groups by left atrial size. The relationship between the left atrial diameter and the National Institutes of Health Stroke Scale score was analyzed apart from the differences in clinical variables.
Results:
No relationship was observed between the left atrial diameter and the National Institutes of Health Stroke Scale score ( r =-0.045 P =0.603). The univariate analysis of both groups revealed that hypertension ( P =0.004), hyperlipidemia ( P =0.001), body mass index ( P =0.000), obesity ( P =0.015), and not stroke etiologic subtypes were associated with left atrial enlargement. In binary logistic regression analysis models, hyperlipidemia 3.384 (95% CI, 1.536 to 7.452), hypertension 2.661 (95% CI, 1.066 to 6.639), and obesity 2.858 (95% CI, 1.158 to 7.052) were significantly associated with the young stroke of left atrial enlargement.
Conclusions:
In young adults, obesity-hyperlipidemia and hypertension were significantly associated with left atrial enlargement in stroke.
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