The usability of neopterin in determining disease course in COVID-19
Duru Mıstanoglu Ozatag1, Pınar Korkmaz1, Havva Keskin1
1From the of Department of Infectious Diseases and Clinical Microbiology (Ozatag, Korkmaz) and from the Department of Biochemistry (Koçak), University of Health Sciences Faculty of Medicine, Kutahya; and form the Department of Internal Medicine (Keskin), Faculty of Medicine, University of Ankara, Ankara, Turkey.
Objectives:
To investigate the usability of neopterin in demonstrating the progression of COVID-19. As a result of uncontrolled activation of COVID-19 monocytes and macrophages, IFN gamma increases and the resulting inflammatory response causes organ damage. IFN released from T cells causes an increase in gamma neopterin levels. Therefore, measurement of neopterin levels can be used to indicate immune system activation and disease progression.
Methods:
The study was carried out prospectively in two different centers. The patients were divided into two groups (mild-moderate and severe) and clinical, laboratory, imaging findings and neopterin levels at hospitalization were compared.
Results:
100 patients were included in our study, 41 of these patients were male. Forty-six patients were identified as severe COVID-19. C-reactive protein, lymphocyte count, fibrinogen, D dimers, lactate dehydrogenase, procalcitonin, troponin and neopterin levels were significant in indicating disease severity. (p<0.05). In ROC analysis, 0.642 for neopterin, 0.698 C-reactive protein, 0.331 lymphocyte count, 0.679 procalcitonin, 0.633 fibrinogen, 0.667 D dimers, 0.655 troponin and 0.706 lactate dehydrogenase were detected and these values were significant.
Conclusion:
In our study, neopterin was detected as an important indicator in determining the course of COVID-19.
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