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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug
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Author Spotlight: Exploring Huotan Jiedu Tongluo Decoction as an Antihypertensive Drug

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Trace element magnesium: a key player in hypertension management

Rajesh Parsanathan1

  • 1Department of Biotechnology, School of Life Sciences, Central University of Tamil Nadu, Neelakudi, Thiruvarur, 610005, Tamil Nadu, India. rajesh.uom@gmail.com.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|August 15, 2023
PubMed

Insights

Magnesium deficiency impairs nitric oxide and increases oxidative stress, contributing to cardiovascular issues. Magnesium supplements may offer benefits for managing these conditions.

Area of Science:

  • Biochemistry
  • Cardiovascular Physiology
  • Cell Biology

Background:

  • Magnesium deficit impacts nitric oxide (NO) production and oxidative stress.
  • Calcium efflux in vascular smooth muscle cells (VSMC) promotes proliferation, migration, and remodeling.

Discussion:

  • These cellular mechanisms are implicated in the pathogenesis of cardiovascular disorders.
  • Imbalances contribute to hypertension, insulin resistance, and fluid/sodium retention, affecting blood volume.

Key Insights:

  • Magnesium's role in regulating NO production and oxidative stress is critical.
  • Calcium dynamics in VSMC are influenced by magnesium levels and impact vascular health.

Outlook:

  • Magnesium supplementation presents a potential therapeutic strategy.
  • Further research into magnesium's cardioprotective effects is warranted.

Keywords:
Cardiovascular healthEndothelial functionHypertensionMagnesiumMagnesium Supplementation

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