Unchanged norepinephrine turnover and concentrations in amygdala-kindled rat brain regions 2 months postseizure

Norepinephrine turnover and concentrations were examined in eight brain regions of amygdala-kindled and yoked control rats. The subjects were killed 2 months after the kindled subjects had exhibited their sixth "stage 4-5" generalized seizure. No significant differences were found in norepinephrine turnover or concentrations between kindled and yoked control rats in any of the brain regions examined. Dopamine turnover and concentrations in brain regions were also unchanged in kindled rats compared with their yoked controls. The data suggest that amygdala kindling does not produce any long-lasting alterations in brain regional catecholamine turnover or concentrations.