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Model of membrane deformations driven by a surface pH gradient.

Toni V Mendes1,2, Jonas Ranft3, Hélène Berthoumieux2,4

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Summary
This summary is machine-generated.

This study models how cellular organelle shapes, like mitochondria cristae, change due to internal biochemical processes. It reveals how pH gradients influence membrane composition and shape, impacting organelle function.

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Area of Science:

  • Biophysics
  • Cell Biology
  • Biochemistry

Background:

  • Cellular organelle shape is linked to metabolic state.
  • Mechanisms coupling biochemical pathways and membrane geometry are under investigation.

Purpose of the Study:

  • To model the coupling between lipid composition and membrane geometry.
  • To investigate the deformation of mitochondria cristae under a pH gradient.

Main Methods:

  • Utilized a generalized Helfrich free energy model.
  • Derived stress tensor and Green's function for tubular membranes.
  • Computed phase diagrams for induced deformations.

Main Results:

  • Developed a model linking lipid composition, membrane geometry, and deformation.
  • Applied the model to mitochondria cristae with a pH gradient.
  • Predicted tube deformations consistent with observed cristae shape changes.

Conclusions:

  • pH gradients can alter membrane lipid composition (e.g., cardiolipins).
  • This alteration drives specific membrane deformations in organelles like mitochondria.
  • The model provides insights into organelle shape regulation and function.