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Updated: Jul 19, 2025

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
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Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of

Rong Zhao1, Pan Wang1, Lin Liu1

  • 1MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, The Clinical Hospital of Chengdu Brain Science Institute, University of Electronic Science and Technology of China, Chengdu, China.

Frontiers in Neuroscience
|August 16, 2023
PubMed
Summary

This study reveals that as Alzheimer's disease (AD) progresses, specific brain regions show altered functional signals and decreased structure-function coupling. The ALFF/VBM ratio effectively tracks cognitive decline in AD patients.

Keywords:
Alzheimer’s diseaseamplitude of low frequency fluctuationsstructure–function couplingvoxel-based morphometrywhite matter

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