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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Causal relationship between circulating lipid traits and periodontitis: univariable and multivariable Mendelian
Gaofu Hu1, Chengjie Song1, Yuxuan Yang1
1Department of Periodontology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Frontiers in Endocrinology
|August 16, 2023
Summary
This study found no genetic evidence linking five circulating lipid traits to periodontitis risk. Further research with larger datasets is needed to explore potential causal relationships between dyslipidemia and gum disease.
Area of Science:
- Genetics
- Periodontology
- Cardiovascular Health
Background:
- Epidemiological studies suggest a correlation between dyslipidemia and periodontitis.
- Confounding factors often limit the interpretation of these observational findings.
- Genetic approaches like Mendelian randomization are needed to establish causality.
Purpose of the Study:
- To investigate the potential genetic causal association between circulating lipid traits and periodontitis.
- To utilize two-sample Mendelian randomization (MR) analysis to overcome confounding factors.
- To assess the causal role of Apolipoprotein A1 (apo A1), Apolipoprotein B (apo B), HDL-C, LDL-C, and TG in periodontitis risk.
Main Methods:
- Two-sample Mendelian randomization (MR) analysis using UK Biobank lipid data and GLIDE consortium periodontitis data.
- Inverse variance weighted (IVW) method for univariable MR, supplemented by sensitivity analyses (Cochran Q, IGX 2, MR-PRESSO, MR-Egger).
- Multivariable MR (MVMR-IVW, MVMR-robust) employed for multiple exposures and validated in an independent cohort.
Main Results:
- Genetically predicted Apolipoprotein A1 (apo A1) showed a potential, albeit low-power, association with periodontitis risk (OR=1.158, P=0.040) in univariable MR.
- Multivariable MR and validation cohort analyses found no significant causal relationship between apo A1 and periodontitis.
- No significant causal associations were detected for Apolipoprotein B (apo B), HDL-C, LDL-C, or TG with periodontitis risk.
Conclusions:
- This MR analysis did not provide genetic evidence supporting a causal link between the five investigated circulating lipid traits and periodontitis.
- Limitations include statistical power and the need for more comprehensive lipid and periodontitis data.
- Further research with larger sample sizes and broader lipid profiles is warranted to clarify the relationship between dyslipidemia and periodontitis.
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