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Thrombosis in multiple myeloma: mechanisms, risk assessment and management

Osnat Jarchowsky1,2, Orly Avnery1,2, Martin H Ellis1,2

  • 1Hematology Institute, Meir Medical Center, Kfar SabaIsrael.

Leukemia & Lymphoma
|August 16, 2023
PubMed

Insights

Multiple myeloma patients face higher thrombosis risks due to disease and treatment factors. Further research is needed for better risk assessment and prophylaxis strategies.

Area of Science:

  • Hematology
  • Oncology
  • Thrombosis Research

Background:

  • Multiple myeloma (MM) significantly elevates the risk of both venous and arterial thrombosis.
  • Thrombosis risk in MM is multifactorial, involving patient-specific, disease-related, and treatment-induced elements.

Purpose of the Study:

  • To review the current understanding of thrombosis in multiple myeloma.
  • To identify key areas for future research in MM-associated thrombosis.

Main Methods:

  • Literature review and synthesis of existing data on MM and thrombosis.
  • Analysis of pathophysiologic mechanisms and risk assessment models.

Main Results:

  • Established risk factors for thrombosis in MM patients include disease activity and specific therapies.
  • Current risk assessment models aid in identifying high-risk individuals for thrombosis.

Conclusions:

  • Risk-adapted thrombosis prophylaxis strategies are recommended for MM patients.
  • Further research into molecular mechanisms, biomarkers, and clinical trials for anticoagulation is crucial.
Keywords:
Venous thromboembolismarterial thrombosisprophylaxisrisk assessment

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