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Legumain: a potential biomarker for atherosclerosis
Bo-Yi Ke1,2, Yu-Sheng Qin3, Lu Cheng1,2
1Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, University of South China, Hengyang 421001, China.
Legumain (LGMN) promotes atherosclerosis development through various mechanisms. This review explores LGMN
Area of Science:
- Biochemistry and Molecular Biology
- Cardiovascular Research
- Immunology
Background:
- Atherosclerosis is a chronic inflammatory disease driven by lipids, posing significant health risks.
- Legumain (LGMN), a cysteine protease, has roles in apoptosis and immune responses.
Approach:
- This review synthesizes current research on Legumain's distribution, structure, generation, and interaction partners.
- It specifically examines the multifaceted relationship between LGMN and the pathophysiological processes of atherosclerosis.
Key Points:
- LGMN promotes atherosclerosis by influencing vascular remodeling, inflammation, plaque stability, and extracellular matrix degradation.
- LGMN activates signaling pathways that drive cell apoptosis and migration, contributing to disease progression.
- LGMN's pro-atherogenic effects are linked to its role in antigen presentation during inflammatory responses.
Conclusions:
- Legumain (LGMN) plays a critical role in the development and progression of atherosclerosis.
- LGMN's involvement in key atherosclerotic mechanisms suggests its potential as a therapeutic target.
- LGMN may serve as a valuable biomarker for atherosclerosis diagnosis and risk assessment.
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