Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

2.3K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
2.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Greater choroid plexus volume is linked to poor sleep, neurodegeneration, and cognitive deficits in older adults: Evidence from the IGNITE Study.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Inflammatory, metabolic, and vascular pathways linking cardiorespiratory fitness to cognition: Results from the IGNITE study.

Brain, behavior, & immunity - health·2026
Same author

Physicochemical Properties, Bioactive Components and Volatile Compounds of Dietary Fatty Acid Balanced Blend Oil.

Foods (Basel, Switzerland)·2026
Same author

Preparation and performance evaluation of a novel Tween 80-based microemulsion system for the remediation of petroleum hydrocarbon-contaminated soil using soil washing test.

Environmental research·2026
Same author

Dual-function acoustic-to-optical transducers for underwater encrypted communication and subwavelength distance measurement.

Science advances·2026
Same author

NUDT1 drives osteosarcoma progression and serves as a robust predictor of clinical outcomes.

Cancer cell international·2026

Related Experiment Video

Updated: Jul 19, 2025

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

21.8K

Citrate-Based Polyester Elastomer with Artificially Regulatable Degradation Rate on Demand.

Lu Wan1, Liangliang Lu2, Xuejiao Liang2

  • 1Key Laboratory of High Performance Polymer Material and Technology of MOE, Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China.

Biomacromolecules
|August 16, 2023
PubMed
Summary

Researchers developed a novel citrate-based polymer (POCSS) with tunable degradation rates for biodegradable implants. This material

More Related Videos

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.5K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.7K

Related Experiment Videos

Last Updated: Jul 19, 2025

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

21.8K
Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.5K
Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites
12:21

Preparation of Monodomain Liquid Crystal Elastomers and Liquid Crystal Elastomer Nanocomposites

Published on: February 6, 2016

12.7K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Citrate-based polymers are widely used for biodegradable implants.
  • Current polymers exhibit passive degradation, limiting clinical adaptability.
  • Personalized medicine demands implants with adjustable degradation profiles.

Purpose of the Study:

  • To develop a novel citrate-based polyester elastomer (POCSS) with an artificially regulatable degradation rate.
  • To incorporate disulfide bonds (S-S) into poly(octamethylene citrate) (POC) for controlled degradation.
  • To evaluate the mechanical, antibacterial, biocompatibility, and degradation properties of the new material.

Main Methods:

  • Synthesis of POCSS by incorporating disulfide bonds into POC crosslinking network.
  • Mechanical property testing and antibacterial assays.
  • In vivo subcutaneous implantation in mice followed by glutathione (GSH) administration to trigger degradation.
  • Assessment of degradation rate changes and biocompatibility through histological analysis and health monitoring.

Main Results:

  • POCSS demonstrated excellent and tunable mechanical properties.
  • The material exhibited notable antibacterial properties and good biocompatibility.
  • Degradation rate was successfully regulated by GSH, increasing 2.46-fold after administration.
  • No significant adverse effects were observed in surrounding tissues or major organs.

Conclusions:

  • The novel POCSS offers a promising solution for biodegradable implants with tunable degradation.
  • The disulfide bond incorporation allows for controlled degradation via GSH stimulus.
  • POCSS shows potential for personalized medical applications due to its adjustable degradation and favorable biocompatibility.