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Magnetically assisted soft milli-tools for occluded lumen morphology detection.

Yingbo Yan^1,2, Tianlu Wang¹, Rongjing Zhang¹

¹Physical Intelligence Department, Max Planck Institute for Intelligent Systems, Stuttgart 70569, Germany.

Science Advances

|August 16, 2023

Summary

A novel miniature soft tool aids in visualizing and crossing complex vascular occlusions. This advancement enhances minimally invasive treatments for endovascular diseases.

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Area of Science:

Biomedical Engineering
Medical Devices
Vascular Surgery

Background:

Intravascular imaging is crucial for diagnosing and treating endovascular diseases.
Current imaging methods struggle with visualizing and crossing complex occlusions.

Purpose of the Study:

To develop a miniature soft tool for enhanced visualization and crossing of complicated occluded vessels.
To improve minimally invasive treatment efficacy for various occlusive morphologies.

Main Methods:

A soft tool combining a magnet-assisted active deformation segment (ADS) and a fluid drag-driven segment (FDS).
ADS utilizes soft-bodied deformation for visualizing fine occlusion details (≥0.5 mm).
FDS employs pulsatile flow fluidic drag for selective entry point detection in severe occlusions (≥0.2 mm).

Main Results:

The ADS successfully visualized partial occlusions with features as small as 0.5 mm.
The FDS automatically detected entry points in severe occlusions with microchannels down to 0.2 mm.
Tool functions were validated in biologically relevant phantoms and ex vivo organs.

Conclusions:

The proposed miniature soft tool effectively visualizes and crosses complex vascular occlusions.
This technology has the potential to enhance minimally invasive medicine for treating occlusive diseases.
The tool offers improved diagnostic and therapeutic capabilities for various circulatory systems.