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Updated: Jul 19, 2025

In vitro Organoid Culture of Primary Mouse Colon Tumors
Published on: May 17, 2013
On the road to colorectal cancer development: crosstalk between the gut microbiota, metabolic reprogramming, and
Anqi Chen1, Zhengting Jiang1, Lingli Cai1
1Clinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, 225001, China.
Abstract:
An increasing number of studies have reported the role of gut microbes in colorectal cancer (CRC) development, as they can be influenced by dietary metabolism and mediate alterations in host epigenetics, ultimately affecting CRC. Intake of specific dietary components can affect gut microbial composition and function, and their metabolism regulates important epigenetic functions that may influence CRC risk. Gut microbes can regulate epigenetic modifications through nutrient metabolism, including histone modification, DNA methylation, and noncoding RNAs. Epigenetics, in turn, determines the gut microbial composition and thus influences the risk of developing CRC. This review discusses the complex crosstalk between metabolic reprogramming, gut microbiota, and epigenetics in CRC and highlights the potential applications of the gut microbiota as a biomarker for the prevention, diagnosis, and therapy of CRC.
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