Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents01:17

Drugs Affecting GI Tract Motility: Opioids as Antidiarrheal Agents

Diarrhea, a condition marked by frequent loose or watery bowel movements, can be triggered by multiple factors such as viral or bacterial infections, food intolerances, anxiety, medications, and digestive disorders. Symptoms may include abdominal pain, bloating, nausea, and cramping. Severe or prolonged diarrhea can lead to complications like electrolyte imbalances, malnutrition, and dehydration if left untreated.
Opioids, widely used antidiarrheal agents, mitigate diarrhea by slowing down...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents01:20

Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents

Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Cholera01:25

Cholera

Cholera is an acute gastrointestinal disease caused by the Gram-negative bacterium Vibrio cholerae. It is transmitted primarily via the fecal-oral route through the ingestion of contaminated water or food.Vibrio cholerae is a motile, Gram-negative bacterium of the family Vibrionaceae, primarily associated with waterborne outbreaks in areas with inadequate sanitation. Although over 200 serogroups of V. cholerae exist, only O1 and O139 are responsible for epidemic cholera. The O1 serogroup,...
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do patients with low volume prostate cancer have prostate specific antigen recurrence following radical prostatectomy?

Journal of clinical pathology·2008
Same author

Seasonal variation of reproductive performance, foetal development and progesterone concentrations of sheep in the subtropics.

Reproduction in domestic animals = Zuchthygiene·2008
Same author

Validation of a soccer skill test for use with females.

International journal of sports medicine·2008
Same author

Assessment of the need to coat particle collection cups of the NGI to mitigate droplet bounce when evaluating nebuliser-produced droplets.

Pharmeuropa scientific notes·2008
Same author

Cooling the NGI - an approach to size a nebulised aerosol more accurately.

Pharmeuropa scientific notes·2008
Same author

Multiplex PCR for differential diagnosis of emerging typhoidal pathogens directly from blood samples.

Epidemiology and infection·2008
Same journal

How important is fiber in the Crohn's disease story?

Gastroenterology·2026
Same journal

Reply to "Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy".

Gastroenterology·2026
Same journal

Critical Appraisal of the Integrin αV-YAP-CTGF Axis in Congestive Hepatopathy.

Gastroenterology·2026
Same journal

A High-Risk Impaction: To Scope or to Stent First?

Gastroenterology·2026
Same journal

Epithelial FOXP3 orchestrates O-glycosylated IL-6 secretion to drive pancreatic fibrocarcinogenesis.

Gastroenterology·2026
Same journal

Reply to "Methodological Considerations on Neonatal Metabolomics and Future Inflammatory Bowel Disease".

Gastroenterology·2026
See all related articles

Related Experiment Video

Updated: Jun 26, 2026

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
09:39

Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

Published on: May 30, 2013

Colonic dysfunction during cholera infection.

P Speelman, T Butler, I Kabir

    Gastroenterology
    |November 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Cholera disrupts normal colon function, leading to impaired water absorption and high potassium secretion. This study reveals the colon

    More Related Videos

    Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
    07:06

    Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

    Published on: December 8, 2014

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
    08:20

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

    Published on: July 12, 2018

    Related Experiment Videos

    Last Updated: Jun 26, 2026

    Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages
    09:39

    Determination of Tolerable Fatty Acids and Cholera Toxin Concentrations Using Human Intestinal Epithelial Cells and BALB/c Mouse Macrophages

    Published on: May 30, 2013

    Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
    07:06

    Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

    Published on: December 8, 2014

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice
    08:20

    Murine Distal Colostomy, A Novel Model of Diversion Colitis in C57BL/6 Mice

    Published on: July 12, 2018

    Area of Science:

    • Gastroenterology
    • Infectious Diseases
    • Physiology

    Background:

    • Cholera is characterized by severe diarrhea due to enterotoxin-induced fluid secretion.
    • The role of the colon in cholera pathophysiology remains incompletely understood.

    Purpose of the Study:

    • To investigate the colon's fluid and electrolyte handling during acute cholera.
    • To assess colonic function during both acute cholera and convalescence.

    Main Methods:

    • Measurements of ileocecal and fecal flow rates in 12 cholera patients.
    • Colonoscopic perfusion to determine net colonic water and ion absorption/secretion rates.
    • Analysis of stool and ileocecal fluid ionic composition.

    Main Results:

    • The colon exhibited minimal net fluid absorption (+0.30 ml/min) during acute cholera.
    • Colonoscopic perfusion revealed a slight mean net fluid secretion (-0.03 ml/min).
    • Significant net absorption of sodium and chloride, but net secretion of potassium and bicarbonate was observed.

    Conclusions:

    • The colon's impaired water absorption contributes to cholera's clinical presentation.
    • High rates of potassium secretion by the colon are a key feature of acute cholera.
    • Colonic function, particularly potassium handling, improves during convalescence.