Circadian variation of susceptibility to gastric mucosal injury by acidified aspirin or absolute ethanol in the rat
View abstract on PubMed
Summary
This summary is machine-generated.Rats exhibit circadian variations in gastric mucosal injury susceptibility. Acidified aspirin causes more damage in the light phase, while ethanol
Area Of Science
- Gastroenterology
- Chronobiology
- Physiology
Background
- Gastrointestinal processes fluctuate, potentially impacting mucosal protection and injury.
- Circadian rhythms coordinate bodily functions and separate incompatible processes.
Purpose Of The Study
- To investigate if susceptibility to gastric mucosal injury from acidified aspirin and ethanol varies with the light/dark cycle in rats.
Main Methods
- Rats were administered acidified aspirin or absolute ethanol at different phases of the light/dark cycle.
- Pretreatment conditions included immobilization and fasting periods.
Main Results
- Acidified aspirin induced significantly more gastric mucosal lesions when given early in the light phase versus the dark phase.
- Absolute ethanol caused greater injury in the light phase, but only in immobilized rats.
- Differences in susceptibility were not affected by immobilization or fasting duration for aspirin.
Conclusions
- Rats demonstrate circadian variation in susceptibility to gastric mucosal injury, particularly from acidified aspirin.
- Environmental factors like immobilization may influence circadian effects on ethanol-induced gastric injury.