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Asthma-II: Pathophysiology and Classification

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...

Asthma: Pathogenesis and Management

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Asthma-III: Symptoms and Complications

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Related Experiment Video

Updated: Jul 19, 2025

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

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Published on: April 16, 2019

TCN1 Expression Is Increased in Asthma.

Changyi Xu^1,2,3, Lijuan Du^1,2, Yubiao Guo^1,2

¹Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-Sen University, Guangdong, China.

International Archives of Allergy and Immunology

|August 16, 2023

Summary

This summary is machine-generated.

TCN1 expression is elevated in asthma patients' sputum and correlates with inflammation and reduced lung function. This suggests TCN1 could be a valuable biomarker for asthma diagnosis and treatment strategies.

Keywords:

Asthma Eosinophilic inflammation Induced sputum Lung function TCN1

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Area of Science:

Respiratory Medicine
Immunology
Biomarker Discovery

Background:

Asthma is a prevalent chronic respiratory disease affecting global populations.
Understanding molecular mechanisms and identifying reliable biomarkers are crucial for effective asthma management.

Purpose of the Study:

To investigate the expression of TCN1 (TCN1) in sputum of asthma patients.
To analyze the correlation between TCN1 expression and key asthma indicators like inflammation and lung function.

Main Methods:

Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blot were used to detect TCN1 mRNA and protein levels.
Enzyme-linked immunosorbent assay (ELISA) quantified TCN1 protein in sputum supernatant.
Correlations with fraction of exhaled nitric oxide (FeNO), IgE, eosinophils (EOS%), lung function parameters, and Th2 cytokines were analyzed.

Main Results:

TCN1 expression was significantly increased in the sputum of asthma patients compared to healthy individuals.
TCN1 levels correlated positively with inflammatory markers (FeNO, IgE, EOS%) and negatively with lung function (e.g., FEV1%pred, FEV1/FVC).
TCN1 expression also showed differential patterns based on asthma severity and increased after inhaled corticosteroid (ICS) treatment.

Conclusions:

Elevated TCN1 expression in sputum is associated with asthma.
TCN1 demonstrates a strong correlation with inflammation and impaired lung function in asthma patients.
TCN1 shows potential as a diagnostic and therapeutic biomarker for asthma.