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Updated: Jul 19, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
39.0K
Biologic therapies for psoriasis and eyes
Alicja Burek-Michalska1, Anna Turno-Kręcicka1, Jane M Grant-Kels2
1Department of Ophthalmology, Wrocław Medical University, Wrocław, Poland.
Clinics in Dermatology
|August 16, 2023
Summary
Psoriasis is an inflammatory disease affecting skin, joints, and eyes. Biologic therapies offer benefits for psoriasis and related uveitis but can cause vision-threatening side effects.
Area of Science:
- Dermatology and Immunology
- Ophthalmology
Background:
- Psoriasis is a systemic inflammatory disorder impacting skin, joints, and eyes.
- Associated comorbidities include metabolic syndrome and coronary plaques.
- Pathomechanism involves genetic factors (e.g., HLA-C*06:02) and immune responses mediated by cytokines like TNF-α and IL-17.
Purpose of the Study:
- To review the role of biologic therapies in managing psoriasis and associated uveitis.
- To highlight the efficacy and potential risks of biologic treatments in these conditions.
Main Methods:
- Literature review of studies on psoriasis, psoriatic arthritis, and uveitis.
- Analysis of treatment outcomes and side effects associated with biologic therapies.
Main Results:
- Biologic therapies are effective in treating psoriasis, psoriatic arthritis, and uveitis in most cases.
- Some biologic agents can lead to serious, vision-threatening side effects in certain patients.
Conclusions:
- Biologic therapy is a key treatment modality for psoriasis and its ocular manifestations.
- Careful monitoring is essential to manage potential adverse events and preserve vision.
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