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Neurotheranostics: The Next Frontier for Health Span
Meryam A Losee1, John P Seibyl2, Phillip H Kuo3
1George Washington School of Medicine, Washington, DC.
Journal of Nuclear Medicine Technology
|August 16, 2023
Summary
Advancements in Alzheimer disease (AD) treatment, including new antiamyloid therapies, offer hope for preventing cognitive decline. Personalized medicine using PET biomarkers like amyloid and tau could revolutionize neurodegenerative disease management.
Area of Science:
- Neurology
- Biomarkers
- Neurotheranostics
Background:
- An aging US population necessitates advancements in treating neurodegenerative diseases like Alzheimer disease (AD).
- Recent approvals of antiamyloid antibodies mark a shift towards mechanism-based AD therapies.
- Early intervention in preclinical AD is crucial for maximizing health span.
Approach:
- Reviewing the paradigm of neurotheranostics for personalized AD treatment.
- Examining the role of Positron Emission Tomography (PET) biomarkers (amyloid, tau, inflammation, neurodegeneration).
- Identifying at-risk populations using AD biomarkers for enrollment in clinical trials.
Key Points:
- Amyloid PET imaging can identify individuals at risk for AD.
- Antiamyloid therapies aim to prevent AD symptom development.
- PET biomarkers can stage AD pathology for tailored treatment.
Conclusions:
- Neurotheranostics and PET biomarkers offer a path towards personalized therapy for AD.
- Targeting disease mechanisms, not just symptoms, is key for future AD treatments.
- Early identification and intervention in AD are critical for effective disease management.
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