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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Combination Therapies and Personalized Medicine02:50

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Related Experiment Video

Updated: Jul 19, 2025

Preparation and Characterization of Lipophilic Doxorubicin Pro-drug Micelles
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Drug delivery methods for cancer immunotherapy.

Edgar Pérez-Herrero1,2, Olivia L Lanier3, Neha Krishnan3

  • 1Departamento de Ingeniería Química y Tecnología Farmacéutica, Universidad de La Laguna, La Laguna, Tenerife, Spain. eperezhe@ull.edu.es.

Drug Delivery and Translational Research
|August 16, 2023
PubMed
Summary

Drug delivery vehicles enhance immunotherapy efficacy for cancers, overcoming resistance and improving treatment. This review focuses on hematological cancers, highlighting advancements in overcoming immunotherapy challenges.

Keywords:
CancerDrug deliveryHematologic cancersHydrogelsImmunotherapyNanocarriers

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Area of Science:

  • Oncology
  • Immunology
  • Nanotechnology

Background:

  • Immunotherapy drugs face challenges like resistance, short half-lives, and delivery issues.
  • Current immunotherapies benefit only a limited patient population.
  • Adverse effects are a significant concern in immunotherapy treatments.

Purpose of the Study:

  • To review the role of drug delivery vehicles in overcoming immunotherapy limitations.
  • To provide an exhaustive overview of drug delivery applications in hematological cancers.
  • To illustrate how drug delivery vehicles enhance immunotherapy efficacy.

Main Methods:

  • Literature review of published studies on drug delivery vehicles in immunotherapy.
  • Focus on applications and advancements in hematological cancer treatment.
  • Analysis of case studies and examples of successful drug delivery strategies.

Main Results:

  • Drug delivery vehicles show promise in enhancing drug half-life and targeted delivery.
  • These vehicles can mitigate resistance and reduce adverse effects associated with immunotherapy.
  • Significant progress has been made in applying these technologies to hematological malignancies.

Conclusions:

  • Drug delivery vehicles are crucial for advancing immunotherapy, particularly in hematological cancers.
  • Overcoming current limitations will broaden patient benefit from immunotherapy.
  • Further research into novel drug delivery systems is warranted for improved cancer treatment outcomes.