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Related Experiment Video

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Generation of a Human iPSC-Based Blood-Brain Barrier Chip

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Published on: March 2, 2020

In situbiosensing technologies for an organ-on-a-chip.

Jinyoung Kim¹, Junghoon Kim¹, Yoonhee Jin²

¹Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea.

|August 17, 2023

Summary

Organoids and organs-on-chips offer ethical, cost-effective in vitro simulations of human organs. Biosensing technology integrated into these organ-on-chip models enables real-time monitoring for pharmaceutical drug development.

Keywords:

biosensing technique multi-organ model organ-on-a-chip real-time monitoring

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Area of Science:

Biotechnology and Biomedical Engineering
Organ-on-a-chip technology
In vitro organ modeling

Background:

In vitro organ simulation addresses limitations of in vivo experiments, including accuracy, ethics, and cost.
Organoids and organs-on-chips are advanced models replicating in vitro organ physiology and real-time biological functions.
These systems are crucial for assessing organ responses to external stimuli.

Purpose of the Study:

To review biosensing technologies for in situ, real-time measurement of organ responses within organ-on-chip systems.
To highlight the application of organ-on-chip technology in pharmaceutical drug development for predicting organ responses.
To discuss the potential of multi-organ-on-a-chip systems in closely mimicking the in vivo environment.

Main Methods:

Review of existing literature on organoid and organ-on-chip technologies.
Focus on biosensing techniques enabling real-time data acquisition from organ-on-chip models.
Discussion of multi-organ-on-a-chip systems and their integration with sensing technologies.

Main Results:

Biosensing technology facilitates in situ, real-time monitoring of organ responses in organ-on-chip systems.
Organ-on-chip platforms, especially multi-organ models, provide a more accurate representation of in vivo conditions.
These systems are highly effective for predicting drug responses in pharmaceutical development.

Conclusions:

Advancements in organ-on-chip technology, coupled with automated multi-sensing, will lead to sophisticated human-on-a-chip systems.
Further development of chip technology and assessment techniques is essential for realizing the full potential of these models.
Organ-on-chip biosensing offers a powerful tool for in vitro drug testing and understanding organ physiology.