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The Emerging Role of LncRNA AWPPH in Multiple Cancers: A Review Study

Mohsen Sheykhhasan1, Fateme Dermani2, Nematollah Gheibi3

  • 1Medical Microbiology Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.

Current Molecular Medicine
|August 17, 2023
PubMed

Insights

Long non-coding RNA WAPPH (lncRNA WAPPH) acts as an oncogene in various human cancers. This review highlights lncRNA WAPPH

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Long non-coding RNAs (lncRNAs) are key regulators of gene expression across epigenetic, transcriptional, post-transcriptional, and translational levels.
  • LncRNAs play a critical role in human malignancies and patient prognosis.
  • lncRNA WAPPH, located on chromosome 2q13, is a newly identified lncRNA with significant implications in cancer.

Purpose of the Study:

  • To comprehensively review and functionally discuss the role of lncRNA WAPPH in various human cancers.
  • To elucidate the oncogenic functions of lncRNA WAPPH in tumorigenesis and cancer progression.
  • To explore the involvement of lncRNA WAPPH in the biological processes of both solid and blood cancers.

Main Methods:

  • Literature review and analysis of existing research studies on lncRNA WAPPH.
  • Functional assessment of lncRNA WAPPH's role in cancer development.
  • Examination of lncRNA WAPPH's involvement in diverse cancer types, including breast, gastric, colorectal, ovarian, bladder cancers, and leukemia.

Main Results:

  • lncRNA WAPPH is frequently deregulated in a wide spectrum of human malignancies.
  • lncRNA WAPPH functions as an oncogene, promoting tumorigenesis and cancer development.
  • lncRNA WAPPH is implicated in various biological processes critical to cancer progression in both solid tumors and hematological malignancies.

Conclusions:

  • lncRNA WAPPH is a significant oncogene in human cancers.
  • lncRNA WAPPH exhibits deregulated expression across numerous cancer types.
  • lncRNA WAPPH holds potential as a diagnostic biomarker and therapeutic target for human malignancies.
Keywords:
AWPPHCancer biomarkerdiagnosislong non-coding RNAneoplasm.therapeutic

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