Pediatric attention deficit hyperactivity disorder (ADHD): 2022 updates on pharmacological management
Lisa O'Connor1, Stephanie Carbone1, Anthony Gobbo1
1Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA.
Expert Review of Clinical Pharmacology
|August 17, 2023
Summary
Pediatric attention-deficit disorder (ADHD) treatments are evolving with new stimulant and non-stimulant medications. This review covers current options, novel agents, and their mechanisms for managing ADHD in youth.
Area of Science:
- Pharmacology
- Neuroscience
- Pediatrics
Background:
- Pediatric attention-deficit disorder (ADHD) affects a significant global population.
- Pharmacologic treatments are established as safe and effective for ADHD symptom management.
- Numerous medication formulations are available, with continuous annual approvals of new agents.
Purpose of the Study:
- To provide an overview of ADHD.
- To review stimulant and non-stimulant medication options for pediatric ADHD.
- To summarize novel and upcoming ADHD medications for youth.
Main Methods:
- Literature search utilizing PubMed and Medline.
- Search terms included "children," "adolescents," "ADHD," and "medication."
- Review of FDA package inserts for all relevant medications.
Main Results:
- New formulations include extended-release methylphenidate (DR/ER MPH) and an amphetamine patch.
- Novel agents include viloxazine extended-release (VER), a selective norepinephrine reuptake inhibitor (SNRI).
- Centanafadine, a triple reuptake inhibitor, is pending approval.
Conclusions:
- The landscape of ADHD pharmacotherapy is expanding with new formulations and agents.
- These advancements offer expanded therapeutic options for managing pediatric ADHD.
- Understanding novel mechanisms and side effect profiles is crucial for effective treatment.
Keywords:
ADHDCentanafadineattention-deficit/hyperactivity disorderdelayed release/Extended-release methylphenidatedextroamphetamineserdexmethylphenidateviloxazine extended-releaseMore Related Videos
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