Sex differences in patterns of referral and resource utilization in the cardiology clinic: an outpatient analysis
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Updated: Jul 19, 2025

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Published on: August 9, 2024
Lourdes Vicent1,2,3, Nicolás Rosillo1,2,4, Guillermo Moreno1,2,5
1Cardiology Department, Hospital Universitario 12 de Octubre, Madrid, Spain.
Insights
Sex differences exist in cardiology referrals, with women experiencing fewer hospitalizations and lower mortality but more emergency visits. These patterns require further investigation to understand underlying causes.
Area of Science:
- Cardiology
- Health Services Research
- Sex Differences in Medicine
Background:
- Management patterns in specialized cardiac care may differ between sexes.
- Understanding these differences is crucial for equitable healthcare delivery.
Purpose of the Study:
- To assess potential sex differences in referral patterns, management, and outcomes for patients attending outpatient cardiology consultations.
- To identify disparities in cardiac care based on sex.
Main Methods:
- Retrospective observational analysis of 5,974 new patients (2017-2018) referred to a tertiary cardiology clinic.
- Comparison of referral reasons, management decisions, and 24-month post-visit outcomes between men and women.
- Analysis included age-related referral rates, common consultation reasons, hospitalizations, mortality, and emergency department visits.
Main Results:
- Women were referred at higher age-related rates, with palpitations as a common reason versus ECG abnormalities in men.
- Despite similar delays in care, women had significantly fewer cardiology hospitalizations (5.8% vs. 9.3%) and lower mortality (1.8% vs. 2.7%).
- Women under 65 had more emergency department visits (48.5% vs. 39.9%) compared to men.
Conclusions:
- Substantial sex differences are evident in primary care cardiology referral patterns, management decisions, and patient outcomes.
- These disparities are only partially explained by age, necessitating further research into the underlying reasons.
- Investigating the drivers of these sex-based differences is essential for improving cardiac care equity.
Aims:
Women may have different management patterns than men in specialised care. Our aim was to assess potential sex differences in referral, management and outcomes of patients attending outpatient cardiac consultations.
Methods And Results:
Retrospective observational analysis of patients ≥18 years referred for the first time from primary care to a tertiary hospital cardiology clinic in 2017-2018, comparing reasons for referral, decisions and post-visit outcomes by sex.A total of 5,974 patients, 2,452 (41.0%) men aged 59.2 ± 18.6 years and 3,522 (59.0%) women aged 64.5 ± 17.9 years (P < 0.001) were referred for a first cardiology consultation. The age-related referral rates were higher in women. The most common reasons for consultation were palpitations in women (n = 676; 19.2%) and ECG abnormalities in men (n = 570; 23.2%). Delays to cardiology visits and additional tests were similar. During 24 months of follow-up, women had fewer cardiology hospitalisations (204; 5.8% vs. 229; 9.3%; P = 0.003) and lower mortality (65; 1.8% vs. 66; 2.7%; P = 0.028), but those aged <65 years had more emergency department visits (756; 48.5% vs. 560; 39.9%, P < 0.001) than men.
Conclusion:
There are substantial sex differences in primary care cardiology referral patterns, including causes, rates, decisions and outcomes, which are only partially explained by age differences. Further research is needed to understand the reasons for these differences.
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