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Chronic Salmonella Infection Induced Intestinal Fibrosis

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Ulcerative colitis complicated by Budd-Chiari syndrome.

I M Chesner, S Muller, J Newman

|September 1, 1986

Summary

Ulcerative colitis can be linked to Budd-Chiari syndrome, a chronic hepatic vein thrombosis. Liver tests may appear normal until late stages, with ascites indicating potential complications.

Area of Science:

Gastroenterology
Hepatology
Vascular Medicine

Background:

Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
Budd-Chiari syndrome (BCS) involves hepatic vein thrombosis.
The association between UC and BCS is uncommon but significant.

Observation:

Two cases of ulcerative colitis presented with chronic Budd-Chiari syndrome.
Hepatic disorder progression was independent of colitis activity.
Initial liver function tests (LFTs) were largely normal, except for elevated alkaline phosphatase and low albumin.

Findings:

A combination of elevated serum alkaline phosphatase, low serum albumin, and ascites in UC patients suggests BCS.
These specific LFT abnormalities can be early indicators of hepatic vein thrombosis.

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Ascites in UC patients warrants investigation for underlying BCS.

Implications:

Early suspicion of Budd-Chiari syndrome is crucial in ulcerative colitis patients with specific LFT abnormalities and ascites.
This highlights the importance of comprehensive diagnostic workups in complex UC cases.
Understanding this association can lead to earlier diagnosis and management of BCS in UC patients.