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Bone health in inflammatory bowel disease
Hao Wei1, Yihan Zhao2, Lisha Xiang1
1Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Expert Review of Gastroenterology & Hepatology
|August 17, 2023
Summary
Inflammatory bowel disease (IBD) can cause osteoporosis, especially in children. Early detection and individualized treatment are key for managing bone complications in pediatric IBD patients.
Area of Science:
- Gastroenterology and Endocrinology
- Pediatric Bone Health
Background:
- Inflammatory bowel disease (IBD) is linked to systemic inflammation and bone complications like osteopenia and osteoporosis.
- Osteoporosis development in IBD is multifactorial, with unique risk factors in pediatric patients, including delayed puberty and growth hormone axis abnormalities.
Purpose of the Study:
- To review the pathophysiology of osteoporosis in adult and pediatric IBD patients.
- To provide evidence-based prevention and treatment strategies, with a focus on pediatric IBD.
Main Methods:
- Literature search of PubMed and Web of Science databases.
- Inclusion of articles on IBD, osteoporosis, pediatric populations, and fracture risk from database inception to February 2023.
Main Results:
- IBD is associated with significant bone complications, including osteoporosis.
- Pediatric IBD patients face distinct osteoporosis risks, differing from adult patients.
- Effective management strategies are available for IBD-related bone issues.
Conclusions:
- Individualized, comprehensive treatment plans are crucial for managing osteoporosis in pediatric IBD.
- Understanding the multifactorial nature of osteoporosis in IBD is essential for effective care.
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