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Updated: Jul 19, 2025
07:34
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma
Published on: August 3, 2022
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COVID-19 patients treated with convalescent plasma.
Lise Sofie Haug Nissen-Meyer1, Magnhild Eide Macpherson2, Linda Gail Skeie2
1Seksjon for blodgivning, Avdeling for immunologi og transfusjonsmedisin, Oslo universitetssykehus.
Summary
COVID-19 convalescent plasma treatment in Norway was generally well-tolerated. Immunocompromised patients receiving this therapy showed potentially lower mortality rates compared to immunocompetent individuals.
Area of Science:
- Infectious Diseases
- Immunology
- Hematology
Background:
- The NORPLASMA project in Norway administered COVID-19 convalescent plasma.
- Initial treatment was for critically ill patients, later restricted to critically ill immunocompromised patients.
Purpose of the Study:
- To describe clinical characteristics, comorbidity, and mortality in patients receiving COVID-19 convalescent plasma.
- To evaluate the safety and potential efficacy of convalescent plasma in different patient groups.
Main Methods:
- An observational study included 79 patients from April 2020 to March 2022.
- Data on immune status, comorbidities, and outcomes were collected from patient records.
- 193 units of convalescent plasma were administered across 15 healthcare facilities.
Main Results:
- The median age of patients was 65 years, with an overall in-hospital mortality of 39% (31 out of 79).
- Among 59 immunocompromised patients, 20 died, versus 11 deaths in 20 immunocompetent patients.
- The treatment was well-tolerated, with only two patients experiencing mild allergic skin reactions.
Conclusions:
- COVID-19 convalescent plasma appears safe for patient treatment.
- Immunocompromised patients may experience a survival benefit from convalescent plasma therapy.
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