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Cellular Membranes and Drug Transport

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.

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Updated: Jul 19, 2025

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Published on: August 28, 2015

Polymer Complex Multilayers for Drug Delivery and Medical Devices.

Wenyuan Lang¹, Hao Huang¹, Li Yang²

¹State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Center for Advanced Low-dimension Materials, College of Materials Science and Engineering, Donghua University, Shanghai 201620, P. R. China.

ACS Applied Bio Materials

|August 17, 2023

Summary

Polymer complex multilayers (PCMs) fabricated using layer-by-layer (LBL) assembly offer versatile platforms for advanced biomedical applications. These biocompatible materials enable controlled drug delivery and enhance medical device performance, with potential for wearable health monitoring.

Keywords:

controlled release drug delivery layer-by-layer medical device polymer complex multilayer

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Area of Science:

Biomaterials Science
Polymer Chemistry
Nanotechnology

Background:

Layer-by-layer (LBL) assembly enables the fabrication of polymer complex multilayers (PCMs) with tunable properties.
Biocompatible PCMs are increasingly utilized in biomedical applications due to their ease of preparation and functional integration capabilities.

Purpose of the Study:

To present recent advancements in the application of PCMs for drug delivery and medical devices.
To highlight the potential of PCMs in developing next-generation wearable health technologies.

Main Methods:

Utilizing LBL assembly to engineer PCMs with specific structures and functionalities.
Investigating the controlled release mechanisms (stimuli-triggered, sustained, spatiotemporal sequential) of drugs from PCM platforms.
Evaluating the impact of PCM coatings on the bioresponse and performance of implantable medical devices.
Exploring the integration of LBL PCMs into flexible electronic and optical elements for wearable devices.

Main Results:

Demonstrated successful application of PCMs for controlled drug delivery systems.
Showcased enhancement of medical device performance and bioresponse regulation through PCM coatings.
Presented the fabrication of flexible electrical and optical components using LBL PCMs.

Conclusions:

PCMs are highly promising for sophisticated drug delivery systems, offering precise control over release kinetics.
PCM coatings significantly improve the functionality and biocompatibility of implantable medical devices.
LBL-assembled PCMs hold substantial potential for advancing wearable devices in disease monitoring and health management.