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Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance

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Metal-Organic Framework for Hypoxia/ROS/pH Triple-Responsive Cargo Release.

Wenyu Chen¹, Huixin He¹, Pengfei Jiao¹

¹School of Pharmacy, Bengbu Medical College, Bengbu, Anhui, 233000, China.

Advanced Healthcare Materials

|August 17, 2023

Summary

This summary is machine-generated.

This study introduces a triple-responsive metal-organic framework (MOF) for enhanced photodynamic therapy (PDT). The MOF releases photosensitizers on demand, improving antitumor efficacy by overcoming reactive oxygen species (ROS) limitations.

Keywords:

drug delivery metal-organic frameworks photodynamic therapy

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Fabrication and Operation of an Oxygen Insert for Adherent Cellular Cultures

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Published on: January 6, 2010

Area of Science:

Biomaterials Science
Nanotechnology
Cancer Therapy

Background:

Photodynamic therapy (PDT) faces challenges with short reactive oxygen species (ROS) lifetimes and limited diffusion distances.
Developing effective drug delivery systems is crucial for enhancing PDT efficacy.

Purpose of the Study:

To design a hypoxia/ROS/pH triple-responsive metal-organic framework (MOF) for triggered photosensitizer release.
To improve antitumor efficacy of PDT by addressing limitations of ROS diffusion and lifetime.

Main Methods:

Synthesized a zinc-based MOF encapsulated with Chlorin e6 (Ce6) photosensitizer, utilizing an azo-containing imidazole ligand.
Investigated the MOF's responsiveness to hypoxia (via azo reduction), acidic pH (via imidazole ionization), and ROS (via imidazole oxidation).
Evaluated the synergistic effects of these triggers on photosensitizer release and PDT efficacy.

Main Results:

The azo group's reduction in hypoxic conditions depleted antioxidants (GSH, Trx), facilitating rapid cargo release.
Imidazole ionization in acidic organelles promoted lysosomal escape and Ce6 release.
ROS-induced imidazole oxidation further enhanced cargo release, demonstrating synergistic effects.
The triple-responsive system improved photosensitizer release rates and enhanced PDT therapy.

Conclusions:

Triple-responsive nanocarriers offer a promising strategy for triggered photosensitizer release in PDT.
This approach effectively overcomes limitations associated with ROS in antitumor PDT.
The developed MOF system demonstrates potential for improved cancer treatment outcomes.