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The onchocerciasis hypothesis of nodding syndrome
Robert Colebunders1, Amber Hadermann1, Joseph Nelson Siewe Fodjo1
1Global Health Institute University of Antwerp, Antwerp, Belgium.
Abstract:
Nodding syndrome (NS) is a phenotypic presentation of onchocerciasis-associated epilepsy (OAE). OAE is an important public health problem in areas with high ongoing Onchocerca volvulus transmission. OAE, including NS, is preventable by strengthening onchocerciasis elimination programs. The presence of tau in OAE postmortem brains could be the consequence of neuroinflammation directly or indirectly induced by O. volvulus. Omics research is needed to investigate whether O. volvulus worms contain a neurotropic virus.
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