Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease of transferrin C2 frequency with age.

L Beckman, G Beckman

    Human Heredity
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    The transferrin C2 variant is linked to adverse health outcomes. Its frequency declines with age, supporting the hypothesis that it increases hydroxyl radical damage risk in individuals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Defining and measuring 'eczema control': an international qualitative study to explore the views of those living with and treating atopic eczema.

    Journal of the European Academy of Dermatology and Venereology : JEADV·2019
    Same author

    Corrigendum to "Associations between neurodevelopmental disorders and factors related to school, health, and social interaction in schoolchildren: Results from a Swedish population-based survey" [Disabil Health J 9(4) (2016) 663-672].

    Disability and health journal·2018
    Same author

    Eczema and educational attainment: a systematic review.

    The British journal of dermatology·2016
    Same author

    Dynamic loading, matrix maintenance and cell injection therapy of human intervertebral discs cultured in a bioreactor.

    European cells & materials·2016
    Same author

    Acute mechanical injury of the human intervertebral disc: link to degeneration and pain.

    European cells & materials·2014
    Same author

    Assortative mating in man.

    The Eugenics review·2011
    Same journal

    Comparative profiles of pediatric Mendeliome: A Single-Centre 572-Whole-Exome Sequencing Study in Xinjiang.

    Human heredity·2026
    Same journal

    Erratum.

    Human heredity·2026
    Same journal

    Exploratory Analysis of HMGB1 Genetic Variants and Their Potential Association with Lung Cancer Susceptibility and Chemotherapy Response in a Chinese Population.

    Human heredity·2025
    Same journal

    Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

    Human heredity·2025
    Same journal

    Generalized Stable Population and Agent-Based Models of Phenotypic Transmission in Human Populations, with an Application to Body Size.

    Human heredity·2025
    Same journal

    Proteinase-activated receptor 2 (PAR-2) expression and F2RL1 genetic variants are associated with asthma: a case-control study in the Chinese population.

    Human heredity·2025
    See all related articles

    Area of Science:

    • Genetics
    • Biochemistry
    • Human Health

    Background:

    • The transferrin C2 variant has been previously associated with spontaneous abortion, prematurity, phototoxic eczema, and rheumatoid arthritis.
    • A proposed mechanism suggests transferrin C2 elevates the risk of cellular damage via hydroxyl radicals.

    Purpose of the Study:

    • To investigate the age-related frequency of the transferrin C2 gene.
    • To test the hypothesis that transferrin C2 frequency decreases with age due to increased oxidative stress.

    Main Methods:

    • Population-based genetic study.
    • Analysis of transferrin C2 gene frequency across different age groups in a northern Swedish population.

    Main Results:

    • The frequency of the transferrin C2 gene was observed to decrease significantly with age.

    Related Experiment Videos

  • Gene frequency dropped from 0.173 in newborns to 0.099 in healthy 70-year-old individuals.

    • Conclusions:

    • The study demonstrates a decrease in transferrin C2 gene frequency with advancing age.
    • This finding supports the hypothesis linking transferrin C2 to increased hydroxyl radical damage and associated health risks.