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Recent progress in tannic acid based approaches as a natural polyphenolic biomaterial for cancer therapy: A review
Motaleb Ghasemian1, Fahimeh Kazeminava2, Ashkan Naseri3
1Department of Medicinal Chemistry, School of Pharmacy, Lorestan University of Medical Science, Khorramabad, Iran.
Abstract:
Significant advancements have been noticed in cancer therapy for decades. Despite this, there are still many critical challenges ahead, including multidrug resistance, drug instability, and side effects. To overcome obstacles of these problems, various types of materials in biomedical research have been explored. Chief among them, the applications of natural compounds have grown rapidly due to their superb biological activities. Natural compounds, especially polyphenolic compounds, play a positive and great role in cancer therapy. Tannic acid (TA), one of the most famous polyphenols, has attracted widespread attention in the field of cancer treatment with unique structural, physicochemical, pharmaceutical, anticancer, antiviral, antioxidant and other strong biological features. This review concentrated on the basic structure along with the important role of TA in tuning oncological signal pathways firstly, and then focused on the use of TA in chemotherapy and preparation of delivery systems including nanoparticles and hydrogels for cancer therapy. Besides, the application of TA/Fe3+ complex coating in photothermal therapy, chemodynamic therapy, combined therapy and theranostics is discussed.
Insights
Tannic acid (TA), a natural polyphenol, shows promise in cancer therapy by targeting oncological pathways and enhancing drug delivery systems. Its applications extend to advanced treatments like photothermal and chemodynamic therapies.
Area of Science:
- Biomedical research
- Natural product chemistry
- Oncology
Background:
- Cancer therapy faces challenges like multidrug resistance, drug instability, and side effects.
- Natural compounds, particularly polyphenols, offer potent biological activities for cancer treatment.
- Tannic acid (TA) is a notable polyphenol with diverse biological features relevant to cancer therapy.
Purpose of the Study:
- To review the structure and role of tannic acid in modulating cancer signaling pathways.
- To explore the application of tannic acid in chemotherapy and drug delivery systems.
- To discuss the use of tannic acid/iron complexes in advanced cancer treatment modalities.
Main Methods:
- Literature review focusing on tannic acid's properties and applications in cancer.
- Analysis of tannic acid's role in oncological signaling pathways.
- Examination of tannic acid in chemotherapy, nanoparticle/hydrogel delivery systems, and TA/Fe3+ complexes.
Main Results:
- Tannic acid exhibits significant anticancer, antiviral, and antioxidant properties.
- TA can be utilized in chemotherapy and integrated into nanoparticle and hydrogel delivery systems.
- TA/Fe3+ complexes show potential in photothermal therapy, chemodynamic therapy, and theranostics.
Conclusions:
- Tannic acid is a versatile natural compound with broad applications in cancer therapy.
- TA can enhance conventional chemotherapy and serve as a component in advanced drug delivery systems.
- The TA/Fe3+ complex holds promise for innovative therapeutic strategies and diagnostics in oncology.
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