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Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
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Smokeless tobacco keratosis.
Curtis J Petruzzelli, Alison Varano1, Andrew Desrosiers
1Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA. avarano@som.geisinger.edu,cmowad@geisinger.edu.
Dermatology Online Journal
|August 17, 2023
Summary
Smokeless tobacco keratosis presents as white lesions on the oral mucosa due to smokeless tobacco use. Biopsy confirmed this benign condition, and tobacco cessation was advised.
Area of Science:
- Oral pathology
- Dermatology
- Oncology
Background:
- Smokeless tobacco use is associated with various oral lesions.
- Smokeless tobacco keratosis is a recognized benign consequence of oral tobacco habit.
Observation:
- A 50-year-old male patient presented with extensive history of smokeless tobacco consumption.
- The patient exhibited characteristic white, gray, or pale macules/papules with wrinkling on the oral mucosa.
Findings:
- Shave biopsy of the oral lesion revealed typical histopathological changes consistent with smokeless tobacco keratosis.
- The condition was confirmed as benign, with no evidence of dysplasia or malignancy.
Implications:
- This case highlights the importance of recognizing smokeless tobacco keratosis in patients with a history of smokeless tobacco use.
- Prompt diagnosis and recommendation for tobacco cessation are crucial for managing this oral mucosal change and preventing potential complications.

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