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Updated: Jul 19, 2025

Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations
Published on: January 10, 2015
Smokeless tobacco keratosis
Curtis J Petruzzelli, Alison Varano1, Andrew Desrosiers
1Geisinger Commonwealth School of Medicine, Scranton, Pennsylvania, USA. avarano@som.geisinger.edu,cmowad@geisinger.edu.
Abstract:
Smokeless tobacco keratosis is a benign lesion characterized by the formation of white, gray, or pale macules or papules with wrinkling or rugae. It forms in the oral mucosa in response to the use of smokeless tobacco products. We present a 50-year-old man with an extensive history of smokeless tobacco use and development of the characteristic lesion. Shave biopsy showed typical changes of this benign condition and tobacco cessation was recommended.

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