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Cost-effectiveness analysis of seasonal influenza vaccination during pregnancy: A systematic review
Zakieh Ostad-Ahmadi1, Sara Boccalini2, Amin Daemi3
1Department of Health Economics, School of Management and Medical Informatics, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Faculty of Management and Medical Information Sciences, Kerman University of Medical Sciences, Kerman, Iran.
Background:
Seasonal influenza vaccination is clinically important and reduces hospitalization costs for pregnant women. However, is it also a cost-effective intervention?
Method:
We conducted a systematic search of Medline (via PUBMED), EMBASE, SCOPUS, and Web of Science databases. We included any economic evaluation studies that reported Incremental Cost-Effectiveness Ratios for vaccinating pregnant women against influenza.
Result:
Out of 927 potentially eligible articles, only 14 full texts met our inclusion criteria. In almost all studies, vaccinating pregnant women was a cost-effective and cost-saving strategy. In one study, it was not cost-effective when the researchers used costs and probabilities related to other groups (healthy adults) due to the lack of data for pregnant women. The main factors influencing the cost-effectiveness of the studies were vaccine efficacy and vaccination cost.
Conclusion:
Influenza vaccination of pregnant women is a cost-effective intervention. More studies on the cost-effectiveness of this intervention in underdeveloped countries are needed.
