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Updated: Jun 15, 2026

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Monitoring of Nanodrug Accumulation in Murine Breast Cancer Metastases

Published on: August 23, 2024

The exit of nanoparticles from solid tumours.

Luan N M Nguyen^1,2, Zachary P Lin^1,2, Shrey Sindhwani^1,2,3

¹Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.

Nature Materials

|August 17, 2023

Summary

Nanoparticles exit solid tumors via lymphatic vessels, not just passive leakage. This finding reveals a new active transport and retention principle for nanomedicine delivery and recirculation in cancer treatment.

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Last Updated: Jun 15, 2026

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Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Evaluation of Nanoparticle Uptake in Tumors in Real Time Using Intravital Imaging

Published on: June 21, 2011

Area of Science:

Biomedical Engineering
Nanotechnology
Cancer Research

Background:

Nanoparticle entry into tumors is understood, but their exit mechanisms remain unclear.
Current models suggest collapsed tumor lymphatic vessels hinder nanoparticle exit, promoting retention.

Purpose of the Study:

To elucidate the mechanisms by which nanoparticles exit solid tumors.
To challenge the existing paradigm of nanoparticle retention in tumors.

Main Methods:

Investigated nanoparticle exit pathways from tumors.
Analyzed the role of lymphatic vessels in nanoparticle transport.
Examined the influence of nanoparticle size on lymphatic exit.

Main Results:

Demonstrated that nanoparticles actively exit tumors through lymphatic vessels.
Showed that the dominant exit mechanism is dependent on nanoparticle size.
Observed that exiting nanoparticles re-enter circulation for potential tumor re-interaction.

Conclusions:

Proposed a new "active transport and retention principle" for nanoparticle delivery to solid tumors.
This principle offers an alternative to the enhanced permeability and retention (EPR) effect.
Provides a novel framework for designing nanomedicines for enhanced cancer therapy and diagnostics.