Factors associated with embryo mosaicism: a systematic review and meta-analysis

Area of Science:

• Reproductive Science
• Genetics
• Embryology

Background:

• Embryonic mosaicism, a condition where an embryo contains cells with different chromosomal numbers, is a significant concern in assisted reproductive technologies.
• Understanding the factors contributing to mosaicism is crucial for improving IVF outcomes and genetic screening accuracy.

Approach:

• A systematic review and meta-analysis of seven studies were conducted.
• Data from IVF cycles within a fertility clinic were also analyzed.
• Key factors investigated included biopsy day, embryo quality, maternal age, paternal age, and seminal quality.

Key Points:

• Embryo mosaicism rates were not associated with embryo quality or seminal quality.
• A higher rate of mosaicism was observed in embryos biopsied on day 6 or 7.
• Embryonic mosaicism was more prevalent in younger women (<34 years) compared to older women (≥34 years).
• Paternal age did not show a significant association with embryo mosaicism.

Conclusions:

• Embryo biopsy day and maternal age are significant factors influencing embryonic mosaicism.
• Embryo quality, seminal quality, and paternal age were not found to be significantly related to mosaicism.
• Identifying causes of mosaicism can lead to improved clinical results in fertility treatments.