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Vaccine Take of RV3-BB Rotavirus Vaccine Observed in Indonesian Infants Regardless of HBGA Status

Celeste M Donato1,2,3, Amanda Handley1,4, Sean G Byars5

  • 1Enteric Diseases Group, Murdoch Children's Research Institute.

The Journal of Infectious Diseases
|August 18, 2023
PubMed

Insights

Histo-blood group antigen (HBGA) status did not impact the effectiveness of the G3P[6] rotavirus vaccine RV3-BB in Indonesian infants. The vaccine demonstrated high vaccine take rates regardless of an infant's HBGA phenotype.

Area of Science:

  • Immunology
  • Vaccinology
  • Genetics

Background:

  • Histo-blood group antigen (HBGA) expression influences rotavirus P genotype binding.
  • Understanding HBGA's role is crucial for vaccine efficacy, particularly for rotavirus vaccines.

Purpose of the Study:

  • To investigate the association between HBGA status and vaccine take of the G3P[6] rotavirus vaccine RV3-BB.
  • To determine if secretor and Lewis phenotypes affect RV3-BB vaccine immunogenicity and viral shedding.

Main Methods:

  • DNA analysis of FUT2 and FUT3 genes from infant stool samples to determine HBGA status (secretor and Lewis phenotypes).
  • Assessment of vaccine take based on serum immune response (IgA, neutralizing antibodies) and/or stool viral excretion.
  • Stratification of participants by HBGA status to analyze vaccine take measures.

Main Results:

  • HBGA status (secretor and Lewis phenotypes) was determined for 147 out of 164 infants.
  • A high cumulative vaccine take rate of 97.9% was observed across participants.
  • No significant association was found between HBGA status (secretor or Lewis phenotype) and overall vaccine take or its individual components.

Conclusions:

  • The G3P[6] rotavirus vaccine RV3-BB achieves high vaccine take in Indonesian infants.
  • HBGA status does not appear to influence the efficacy of the RV3-BB vaccine in this population.
Abstract

Keywords:
Indonesiahisto-blood group antigenneonatal vaccinationrotavirusvaccine take

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