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Pulmonary tumor thrombotic microangiopathy: Exploration into current diagnostic aids and therapeutics

Pavithra Ramakrishnan1, Garima Dahiya2, Meghan Lindstrom3

  • 1Department of Medicine University of Minnesota Minneapolis Minnesota USA.

Pulmonary Circulation
|August 18, 2023
PubMed

Insights

Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare cause of pulmonary hypertension and right heart failure. Early diagnosis is crucial for treatment and survival, as delayed identification often leads to fatal outcomes.

Area of Science:

  • Cardiovascular Medicine
  • Pulmonary Medicine
  • Oncology

Background:

  • Pulmonary tumor thrombotic microangiopathy (PTTM) is a rare vascular disorder.
  • It is characterized by microthrombi in the pulmonary vasculature.
  • PTTM can lead to severe pulmonary hypertension and right heart failure.

Observation:

  • Two cases of PTTM are presented, both diagnosed postmortem.
  • The patients experienced fulminant right ventricle failure.
  • Diagnosis was significantly delayed in both instances.

Findings:

  • PTTM is an under-recognized cause of pulmonary hypertension.
  • High mortality is associated with PTTM, often due to diagnostic delays.
  • Timely identification and treatment are critical for patient outcomes.

Implications:

  • This case series underscores the importance of considering PTTM in patients with unexplained pulmonary hypertension and right heart failure.
  • Prompt diagnostic evaluation may improve survival rates for PTTM.
  • Further research is needed to improve early detection and therapeutic strategies for PTTM.
Keywords:
cancermetastasispulmonary hypertensionright heart catheterizationright ventricle

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