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Suitable bases for patch testing in tropical countries.

A K Bajaj, S C Gupta, A Chatterjee

    International Journal of Dermatology
    |July 1, 1986
    PubMed
    Summary
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    For contact dermatitis, Plastibase and polyethylene glycol 400 are suitable topical medicament bases for tropical climates. Plastibase showed fewer positive reactions than polyethylene glycol, indicating better suitability.

    Area of Science:

    • Dermatology
    • Allergy and immunology
    • Pharmaceutical sciences

    Background:

    • Contact dermatitis is a common skin reaction to topical medications.
    • Selecting appropriate bases for topical medicaments is crucial, especially in tropical regions.
    • Previous studies have not definitively identified optimal bases for use in hot and humid climates.

    Purpose of the Study:

    • To evaluate the suitability of various pharmaceutical bases for topical medicaments in tropical countries.
    • To identify bases that minimize irritant or allergic reactions in patients with suspected contact dermatitis.
    • To compare the efficacy of Plastibase and polyethylene glycol 400 as potential bases.

    Main Methods:

    • Patch testing was conducted on patients with suspected contact dermatitis.

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  • Various pharmaceutical bases were used to deliver topical medicaments.
  • Positive reaction rates were recorded for each tested base.

    • Main Results:

    • Plastibase and polyethylene glycol 400 demonstrated the lowest rates of positive reactions.
    • Polyethylene glycol 400 showed a higher incidence of positive reactions compared to Plastibase.
    • Both bases were identified as potentially suitable for use in tropical environments.

    Conclusions:

    • Plastibase is a highly suitable base for topical medicaments in tropical countries due to minimal positive reactions.
    • Polyethylene glycol 400 is also a viable option but may elicit more reactions than Plastibase.
    • Further research may explore long-term efficacy and patient acceptance of these bases in diverse tropical populations.