Phytocannabinoid-rich galenic preparations for topical administration: extraction and stability testing.

Area of Science:

• Dermatology
• Pharmacology
• Galenic Pharmacy

Background:

• Medical cannabis legalization in Czechia (2013) permits topical treatments for skin disorders.
• Limited implementation of medical cannabis galenic formulations is attributed to a lack of standardized preparation protocols.
• Cannabinoids like cannabidiol (CBD) and tetrahydrocannabinol (THC) demonstrate therapeutic potential for conditions including atopic dermatitis, psoriasis, and acne.

Purpose of the Study:

• To evaluate the cannabinoid extraction capacity of various pharmaceutical bases.
• To assess the stability of cannabinoids within prepared galenic formulations for dermatological use.
• To propose a standardized, easily implementable preparation protocol for pharmacies and medical facilities.

Main Methods:

• Extraction efficiency of different pharmaceutical bases for cannabinoids was assessed.
• Stability of tetrahydrocannabinol (THC) and cannabidiol (CBD) in galenic formulations was monitored over time.
• Physical and chemical properties of bases were correlated with cannabinoid stability and extraction.

Main Results:

• Cannabinoid stability in formulations was dependent on the base's properties.
• Highest THC decomposition occurred in cream bases (up to 5.4%/week) and Vaseline (up to 5.6%/week).
• CBD demonstrated greater stability than THC; olive oil and Synderman bases showed highest extraction (approx. 70%) and stability.

Conclusions:

• A fast and easily implementable preparation protocol for medical cannabis topical formulations has been proposed.
• Olive oil and Synderman bases are recommended for optimal cannabinoid extraction and stability in dermatological preparations.
• Standardized protocols are crucial for the wider implementation of medical cannabis in healthcare for skin conditions.