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Related Experiment Video

Updated: Jul 19, 2025

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
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Colostrum and Preterm Babies: A Systematic Review.

Ethan Slouha1, Zoe S Anderson1, Nana Mansa N Ankrah1

  • 1Anatomical Sciences, St. George's University School of Medicine, True Blue, GRD.

Cureus
|August 18, 2023
PubMed
Summary
This summary is machine-generated.

Early colostrum administration in preterm infants enhanced gut microbiota and immune responses but did not significantly reduce the incidence of NEC, LOS, or VAP. However, it did improve feeding times and shorten hospital stays.

Keywords:
colostrumenteral feedingnecrotizing enterocolitispreterm babysepsisventilatory acquired pneumonia

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Area of Science:

  • Neonatal Medicine
  • Immunology
  • Microbiome Research

Background:

  • Preterm infants are susceptible to infections like necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and ventilator-associated pneumonia (VAP).
  • Maternal colostrum contains immunomodulatory factors (immunoglobulins, lactoferrin, oligosaccharides) that support gut health and immune function.

Purpose of the Study:

  • To evaluate the impact of early colostrum administration on preterm infants' health outcomes.
  • To assess effects on gut microbial composition, inflammatory markers, and incidence of major neonatal morbidities.

Main Methods:

  • Systematic literature review of meta-analyses and experimental studies using PubMed, ScienceDirect, and ProQuest.
  • Keywords: 'colostrum and preterm', 'colostrum and necrotizing enterocolitis'.
  • Inclusion criteria focused on studies examining colostrum's effects in preterm infants.

Main Results:

  • Colostrum intake increased beneficial bacteria (Lactobacillus, Bifidobacterium) and decreased harmful bacteria (Moraxellaceae, Staphylococcaceae).
  • Salivary secretory IgA levels rose, with decreased IL-1b and IL-8, while TNF-a and IFN-g were lower compared to controls.
  • No significant differences in NEC, LOS, or VAP incidence; however, improved time to full enteral feeding and reduced hospital stays were observed.

Conclusions:

  • Early colostrum administration positively modulates the preterm infant gut microbiome and immune status.
  • While not reducing major morbidities, colostrum shows potential benefits in improving feeding tolerance and hospital length of stay for preterm infants.