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Renal function in the obese Zucker rat.

W D Fiske, R A Blouin, B Mitchell

    International Journal of Obesity
    |January 1, 1986
    PubMed
    Summary

    Obese Zucker rats show varied kidney function changes. While glomerular filtration rate and renal plasma flow were similar, tubular function differed, especially when corrected for weight, suggesting obesity-related kidney alterations.

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    Area of Science:

    • Nephrology
    • Animal Models
    • Obesity Research

    Background:

    • Genetically obese Zucker rats (fa/fa) exhibit larger kidneys and progressive glomerular sclerosis.
    • Understanding renal function in obesity is crucial for metabolic disease research.

    Purpose of the Study:

    • To evaluate glomerular filtration rate (GFR), effective renal plasma flow (ERPF), and renal tubular function in obese Zucker rats compared to lean controls.
    • To investigate potential obesity-associated changes in kidney structure and function.

    Main Methods:

    • Study 1: Measured GFR (inulin clearance) and ERPF (p-aminohippurate clearance) in lean Zucker (FA/-), obese Zucker (fa/fa), and Sprague-Dawley (S-D) rats.
    • Assessed renal tubular transport maximum (Tm) for p-aminohippurate.
    • Study 2: Evaluated GFR (creatinine clearance) and performed histological analysis in lean and obese Zucker rats.

    Main Results:

    • No significant differences in GFR or ERPF were observed between lean and obese Zucker rats, or Sprague-Dawley rats.
    • A significant difference in renal tubular transport maximum (Tm) for p-aminohippurate was found between Sprague-Dawley and lean Zucker rats, but not between lean and obese Zucker rats.
    • When corrected for body or kidney weight, comparisons between lean and obese Zucker rats showed significant differences in GFR, ERPF, and Tm.
    • Obese Zucker rats exhibited significantly higher creatinine clearance in Study 2, but histological studies showed no remarkable differences.

    Conclusions:

    • Obesity in Zucker rats is associated with significant alterations in renal tubular function and potentially GFR and ERPF when normalized for weight.
    • There is considerable inter-animal variability in obesity-related kidney function and pathology in the fa/fa rat model.
    • Further research is needed to elucidate the mechanisms behind these observed renal changes in obesity.

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