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Updated: Jul 19, 2025

Robotic Ablation of Atrial Fibrillation
11:21

Robotic Ablation of Atrial Fibrillation

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Atrial fibrillation ablation in patients with arrhythmia-induced cardiomyopathy: a prospective multicentre study

Teba González-Ferrero1,2,3, Marco Bergonti4,5,6, José Nicolás López-Canoa3,7

  • 1Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Santiago de Compostela, Spain.

ESC Heart Failure
|August 18, 2023
PubMed

Insights

Arrhythmia-induced cardiomyopathy (AiCM) affects 17.56% of atrial fibrillation (AF) patients undergoing ablation. Persistent AF and chronic kidney disease predict AiCM, which improves after ablation with similar recurrence rates to non-AiCM patients.

Area of Science:

  • Cardiology
  • Electrophysiology
  • Heart Failure Research

Background:

  • Atrial fibrillation (AF) can lead to arrhythmia-induced cardiomyopathy (AiCM).
  • Catheter ablation (CA) is a treatment option for AF, but its effect on AiCM requires further investigation.
  • Understanding predictors and outcomes of AiCM post-ablation is crucial for patient management.

Purpose of the Study:

  • To investigate the clinical and biochemical characteristics of patients with AF undergoing CA who develop AiCM.
  • To assess the long-term outcomes of CA in patients with and without AiCM.
  • To identify predictors of AiCM development and recurrence after CA.

Main Methods:

  • Prospective multicentre study of consecutive AF patients undergoing CA.
  • AiCM defined by heart failure development with AF and ≥10% improvement in left ventricular ejection fraction 6 months post-ablation.
  • Biomarker analysis (galectin-3, FABP4, sRAGE) in a subgroup of patients.

Main Results:

  • 17.56% of 769 AF patients developed AiCM.
  • Predictors of AiCM included persistent AF, male gender, left atrial volume, QRS width, smoking, and chronic kidney disease (CKD).
  • Biomarkers (sRAGE, FABP4, galectin-3) did not predict AiCM or recurrence. AF recurrence rates were similar between AiCM and non-AiCM groups (30.83% vs. 27.77%).

Conclusions:

  • AiCM development in AF patients undergoing ablation is associated with persistent AF and CKD.
  • Biomarker analysis did not predict AiCM or recurrence.
  • Patients with AiCM benefit from CA, showing improved left ventricular ejection fraction and comparable AF recurrence rates to those without AiCM.
Abstract

Keywords:
Atrial fibrillationCatheter ablationHeart failure

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