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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
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The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Related Experiment Video

Updated: Jul 19, 2025

A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy
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A Precision Medicine Tool for Measurement and Monitoring of Hemoglobin S in Sickle Cell Disease Patients Receiving Transfusion Therapy

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Novel approaches to measure transfusion effectiveness.

Marianne Elaine McPherson Yee1,2, Ross M Fasano1,3

  • 1Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta.

Current Opinion in Hematology
|August 18, 2023
PubMed
Summary

Personalizing red blood cell (RBC) transfusions involves assessing tissue oxygenation and RBC survival, moving beyond simple hemoglobin levels. This approach optimizes transfusion effectiveness for patients with acute or chronic needs.

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Area of Science:

  • Biomedical Engineering
  • Hematology
  • Medical Diagnostics

Background:

  • Transfusion effectiveness is critical for patients requiring acute or chronic red blood cell (RBC) support.
  • Current transfusion guidelines often rely solely on hemoglobin levels, potentially overlooking individual patient needs.

Approach:

  • This review explores advanced methods for evaluating transfusion effectiveness beyond traditional markers.
  • Noninvasive techniques like near-infrared spectroscopy (NIRS) and specialized MRI assess tissue and cerebral oxygenation.
  • Biotin-labeling of RBCs enables precise measurement of RBC survival, including 24-hour recovery and mean lifespan.

Key Points:

  • Tissue oxygenation and RBC survival are key determinants of transfusion effectiveness.
  • NIRS and MRI offer noninvasive ways to monitor oxygen utilization.
  • Biotin-labeling allows for detailed analysis of RBC viability post-transfusion.

Conclusions:

  • Personalized transfusion strategies can be developed by integrating oxygenation and RBC survival data.
  • This individualized approach moves beyond single-marker thresholds like hemoglobin.
  • Optimizing transfusions improves patient outcomes in both acute and chronic settings.