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Prevention of Preterm Labor by Isosorbide Dinitrate and Nitroglycerin Patch
Masoumeh Ghafarzadeh1, Amir Shakarami2, Fatemeh Yari3
1Department of Obstetrics and Gynecology, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Cardiovascular & Hematological Disorders Drug Targets
|August 18, 2023
Summary
Transdermal nitroglycerin (TNG) patches are more effective than isosorbide dinitrate (ISD) tablets in delaying preterm labor. Both treatments showed similar side effect rates, but TNG offered superior labor delay for pregnant women.
Area of Science:
- Obstetrics and Gynecology
- Pharmacology
- Neonatal Medicine
Background:
- Preterm labor is a leading cause of pregnancy hospitalization.
- It can result in severe complications for newborns.
- Effective interventions are crucial for improving neonatal outcomes.
Purpose of the Study:
- To compare transdermal nitroglycerin (TNG) patches and sublingual isosorbide dinitrate (ISD) tablets.
- To evaluate their efficacy in preventing preterm delivery.
- To assess side effect profiles of both medications.
Main Methods:
- A single-blinded clinical trial involving 110 pregnant women (24-34 weeks gestation).
- Randomized groups received either TNG patches or ISD tablets.
- Exclusion criteria included complications like hypotension or headache post-medication.
Main Results:
- 58 patients completed the study (29 per group).
- Transdermal nitroglycerin (TNG) significantly delayed preterm labor and improved recovery time compared to isosorbide dinitrate (ISD).
- No significant differences in complications or contraction frequency were observed between groups.
Conclusions:
- Transdermal nitroglycerin (TNG) is more effective than isosorbide dinitrate (ISD) for delaying preterm labor.
- Both medications appear to have comparable rates of side effects.
- TNG demonstrates a clinical advantage in managing preterm labor.
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