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Physicochemical Stimulus-Responsive Systems Targeted with Antibody Derivatives.

Rezvan Mohammadi¹, Sepideh Ghani^1,2,3, Roghaye Arezumand⁴

¹Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Current Molecular Medicine

|August 18, 2023

Summary

Antibody fragments and monoclonal antibodies are advancing drug delivery. These antibody-conjugated stimuli-responsive systems offer targeted therapies and improved diagnostics for better medical treatments.

Keywords:

Antibody derivatives of antibody endogenous stimuli exogenous stimuli stimulus-responsive systems targeted delivery of antibody.

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Area of Science:

Biotechnology
Nanomedicine
Drug Delivery Systems

Background:

Recombinant antibody technology has enabled monoclonal antibodies (mAbs) and antibody fragments for targeted drug delivery.
Antibody modifications allow for integration into stimuli-responsive systems for controlled release and enhanced targeting.
These systems respond to various endogenous and exogenous stimuli, broadening therapeutic applications.

Purpose of the Study:

To review recent advancements in antibody-conjugated stimuli-responsive systems.
To highlight their impact on modern medicine, diagnostics, and treatment strategies.
To discuss the potential of dual/multi-responsive antibody systems.

Main Methods:

Review of literature on antibody-conjugated stimuli-responsive drug delivery systems.
Analysis of therapeutic and diagnostic applications of modified antibodies.
Focus on systems responding to endogenous and exogenous stimuli.

Main Results:

Antibody-based stimuli-responsive systems demonstrate regulated drug release and precise targeting.
Conjugation with diverse stimuli-responsive materials enables response to a wide range of triggers.
These systems show promise in improving diagnostic and treatment strategies.

Conclusions:

Antibody-conjugated stimuli-responsive systems represent a significant advancement in medicine.
Their ability to respond to specific stimuli enhances therapeutic efficacy and diagnostic accuracy.
Further development of dual/multi-responsive systems will expand their clinical utility.