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Updated: Jul 19, 2025

Human Ex vivo Wound Model and Whole-Mount Staining Approach to Accurately Evaluate Skin Repair
Published on: February 17, 2021
[Skin aging exposome]
Jean Krutmann1, Susanne Grether-Beck2, Eugenia Makrantonaki3,4,5
1IUF - Leibniz-Institut für umweltmedizinische Forschung, Auf'm Hennekamp 50, 40225, Düsseldorf, Deutschland. jean.krutmann@iuf-duesseldorf.de.
Abstract:
The skin is a barrier organ and thus exposed to environmental factors from birth, which essentially determine skin aging. In order to describe and understand this complex process exactly, we applied the concept of the "exposome" to the environmentally induced skin aging process. In this review, we summarize current knowledge on the skin aging exposome. In this context, we characterize the most important exposomal factors, address their relative importance for skin aging and also the relevance of their mutual interactions. Finally, we discuss the clinical consequences resulting from this concept for an effective prevention of skin aging.
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