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Updated: Jul 19, 2025

Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring
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Imaging local diffusion in microstructures using NV-based pulsed field gradient NMR.

Fleming Bruckmaier1, Robin D Allert1, Nick R Neuling1

  • 1Department of Chemistry, TUM School of Natural Sciences, Technical University of Munich, 85748 Garching, Germany.

Science Advances
|August 18, 2023
PubMed
Summary
This summary is machine-generated.

We developed a new nuclear magnetic resonance (NMR) technique using nitrogen-vacancy (NV) centers to precisely measure molecular diffusion and flow in microscopic volumes. This method overcomes limitations of traditional magnetic resonance imaging for studying complex microstructures.

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Area of Science:

  • Physics
  • Materials Science
  • Biophysics

Background:

  • Diffusion in microstructures is vital across neuroscience, medicine, and energy research.
  • Magnetic resonance (MR) methods are standard for diffusion measurement but have spatial encoding limitations.
  • Probing diffusion at the microscale is essential for understanding complex systems.

Purpose of the Study:

  • To introduce nitrogen-vacancy (NV) center-based nuclear MR (NMR) spectroscopy for probing diffusion in microscopic sample volumes.
  • To develop an experimental scheme combining pulsed gradient spin echo (PGSE) with optically detected NV-NMR.
  • To enable local quantification of molecular diffusion and flow.

Main Methods:

  • Combined pulsed gradient spin echo (PGSE) with optically detected NV-NMR spectroscopy.
  • Developed a correlated optical imaging and spatially resolved PGSE NV-NMR experimental scheme.
  • Probed anisotropic water diffusion within an individual model microstructure.

Main Results:

  • Successfully quantified local molecular diffusion and flow using NV-NMR.
  • Demonstrated spatially resolved PGSE NV-NMR experiments.
  • Visualized anisotropic water diffusion in a model microstructure.

Conclusions:

  • Optically detected PGSE NV-NMR is a powerful tool for investigating diffusion in microstructures.
  • This technique overcomes limitations of conventional MR imaging.
  • Future applications include probing single cells, tissue microstructures, and ion mobility in battery materials.