Jove
Visualize
Contact Us

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The posterior approach for removal of all thoracic disc herniations: a single-surgeon experience using the partial transpedicular approach with ultrasonic bone aspiration and ultrasound guidance in 108 consecutive patients.

Journal of neurosurgery. Spine·2026
Same author

BioTriplex: a full-text annotated corpus for fine-tuning language models in gene-disease relation extraction tasks.

Bioinformatics (Oxford, England)·2026
Same author

Contrast-Enhanced Ultrasound Perfusion Imaging of the Spinal Cord Before and After Surgical Decompression for Cervical Spondylotic Myelopathy.

Neurosurgery·2025
Same author

A landmine during cranioplasty: unusual rupture of a previously undiagnosed aneurysm. Illustrative case.

Journal of neurosurgery. Case lessons·2025
Same author

Diagnostic precision, safety, and patient experience of the freehand transperineal prostate biopsy technique under local anesthesia - A single-center experience.

Indian journal of urology : IJU : journal of the Urological Society of India·2025
Same author

Undergraduate pharmacy placements in the primary care clinical environment: An exploration of students' experiences of a pilot placement.

Currents in pharmacy teaching & learning·2025
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 19, 2025

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models
04:30

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models

Published on: March 8, 2024

772

Extreme Paralysis Following Rocuronium Administration in a Myasthenia Gravis Patient: A Case Report.

Kelsey Billups1, Charlotte Collins2, Aimee Weber3

  • 1Medical University of South Carolina, Department of Pharmacy, Charleston, South Carolina.

Clinical Practice and Cases in Emergency Medicine
|August 18, 2023
PubMed
Summary

Patients with myasthenia gravis (MG) may experience prolonged paralysis after rocuronium use during rapid sequence intubation (RSI). Careful dosing and personalized care are crucial for managing neuromuscular blocking agents in this population.

More Related Videos

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

81.3K
Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Published on: March 1, 2015

105.9K

Related Experiment Videos

Last Updated: Jul 19, 2025

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models
04:30

Author Spotlight: Translational Applications of Stimulated SFEMG in Rodent Models

Published on: March 8, 2024

772
Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients
09:44

Manual Muscle Testing: A Method of Measuring Extremity Muscle Strength Applied to Critically Ill Patients

Published on: April 12, 2011

81.3K
Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer
19:53

Single-stage Dynamic Reanimation of the Smile in Irreversible Facial Paralysis by Free Functional Muscle Transfer

Published on: March 1, 2015

105.9K

Area of Science:

  • Emergency Medicine
  • Neuromuscular Pharmacology

Background:

  • Myasthenia gravis (MG) presents unique challenges for neuromuscular blocking agents (NMBAs) during rapid sequence intubation (RSI).
  • Patients with MG exhibit atypical sensitivity and resistance to NMBAs due to altered acetylcholine receptor function.
  • The prolonged duration of rocuronium's effects in MG patients during RSI is not well-quantified in emergency settings.

Purpose of the Study:

  • To highlight the potential for prolonged paralysis with rocuronium in myasthenia gravis patients.
  • To emphasize the need for individualized dosing strategies for neuromuscular blocking agents in MG.

Main Methods:

  • Case report detailing a patient with myasthenia gravis undergoing rapid sequence intubation.
  • Administration of a standard dose of rocuronium (1.2 mg/kg) for RSI.
  • Observation of prolonged paralysis duration and response to sugammadex reversal.

Main Results:

  • A single case demonstrated a 232-minute duration of paralysis following a full RSI dose of rocuronium in an MG patient.
  • Paralysis was confirmed by the delayed effect of the reversal agent sugammadex.
  • Sustained paralysis necessitated emergent neurosurgical intervention.

Conclusions:

  • Rocuronium, if not dose-reduced, can cause paralysis lasting up to four hours in myasthenia gravis patients.
  • Emergency physicians must be aware of the challenges and risks associated with NMBAs in MG.
  • Personalized patient care before, during, and after RSI is essential for managing myasthenia gravis.