Related Experiment Video

Updated: Jul 19, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
07:24

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos

Published on: December 13, 2018

6.5K

Long non-coding RNAs in lung cancer: Unraveling the molecular modulators of MAPK signaling

Md Sadique Hussain1, Obaid Afzal2, Gaurav Gupta3

  • 1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, 302017 Jaipur, Rajasthan, India.

Pathology, Research and Practice
|August 18, 2023
PubMed

Insights

Long non-coding RNAs (lncRNAs) regulate the MAPK pathway in lung cancer (LC). Understanding lncRNA-MAPK interactions is key for developing novel LC treatments and targeting tumor growth.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Lung cancer (LC) remains a major global health challenge.
  • The mitogen-activated protein kinase (MAPK) signaling pathway is implicated in LC progression.
  • The precise regulatory roles of long non-coding RNAs (lncRNAs) in MAPK signaling within LC are not fully understood.

Purpose of the Study:

  • To review the role of lncRNAs in regulating MAPK signaling in lung cancer.
  • To explore the molecular mechanisms by which lncRNAs influence MAPK pathway activity in LC.
  • To highlight the potential of lncRNAs as therapeutic targets for lung cancer.

Main Methods:

  • Literature review of recent research on lncRNAs and MAPK signaling in lung cancer.
  • Analysis of experimental findings on lncRNA function in LC.
  • Examination of the molecular mechanisms connecting lncRNAs to MAPK pathway dysregulation.

Main Results:

  • lncRNAs are critical regulators of cellular processes, including cancer growth.
  • Dysregulated lncRNAs are associated with LC cell death, metastasis, and proliferation.
  • lncRNAs can act as oncogenes or tumor suppressors in lung cancer.

Conclusions:

  • lncRNAs play a significant role in modulating MAPK signaling in lung cancer.
  • Targeting lncRNA-MAPK interactions presents a promising avenue for novel lung cancer therapies.
  • Further research into lncRNA functions can advance understanding and treatment of lung cancer.
Keywords:
LncRNAsLung cancerMAPKMetastasisMolecular mechanisms

More Related Videos

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

7.7K
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells07:23

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

450

Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
5.7K
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
64.0K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K